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Assay Detail

CHEMBL617520

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [3H]DOB from human 5-hydroxytryptamine 2A receptor
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Expert

Target

5-hydroxytryptamine receptor 2A (CHEMBL224)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Evaluation of isotryptamine derivatives at 5-HT(2) serotonin receptors.
Chang-Fong J, Addo J, Dukat M, Smith C, Mitchell NA, Herrick-Davis K, Teitler M, Glennon RA.
Bioorg Med Chem Lett (2002) 12 : 155 -158
PubMed 11755343 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 12 6.48 7.22

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL289061 1 7.22
CHEMBL290779 1 7.10
CHEMBL40816 1 6.64
CHEMBL39417 1 6.52
CHEMBL443258 1 6.50
CHEMBL288445 1 6.48
CHEMBL6393 1 6.20
CHEMBL38633 1 6.19
CHEMBL269073 1 6.03
CHEMBL6385 1 5.89
CHEMBL6503 1 -
CHEMBL41806 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL289061 Ki = 60.0 nM 7.22
CHEMBL290779 Ki = 80.0 nM 7.10
CHEMBL40816 Ki = 230.0 nM 6.64
CHEMBL39417 Ki = 300.0 nM 6.52
CHEMBL443258 Ki = 320.0 nM 6.50
CHEMBL288445 Ki = 330.0 nM 6.48
CHEMBL6393 Ki = 635.0 nM 6.20
CHEMBL38633 Ki = 650.0 nM 6.19
CHEMBL269073 Ki = 930.0 nM 6.03
CHEMBL6385 Ki = 1300.0 nM 5.89
CHEMBL6503 Ki > 10000.0 nM -
CHEMBL41806 Ki > 10000.0 nM -