Assay Detail
Binding
CHEMBL617527
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Affinity on 5-hydroxytryptamine 2 receptor labeled by [125I]DOI
4
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Serotonin 2 (5-HT2) receptor (CHEMBL2093870) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
Benzofuran bioisosteres of hallucinogenic tryptamines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 7.45 | 7.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL7257 | MEBUFOTENIN | 2.0 | 1 | 7.82 |
| CHEMBL304628 | — | — | 2 | 7.57 |
| CHEMBL62426 | — | — | 1 | 7.02 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL7257 | MEBUFOTENIN | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL304628 | — | Ki | = | 27.1 | nM | 7.57 |
| CHEMBL304628 | — | Ki | = | 42.0 | nM | 7.38 |
| CHEMBL62426 | — | Ki | = | 95.0 | nM | 7.02 |