Assay Detail
Binding
CHEMBL617528
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Affinity towards [3H]- DOB -labeled 5-hydroxytryptamine 2 receptor sites in rat cortical homogenates
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Serotonin 2 (5-HT2) receptor (CHEMBL2093870) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
N-methyl derivatives of the 5-HT2 agonist 1-(4-bromo-2,5-dimethoxyphenyl)-2-aminopropane.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 7.90 | 9.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL69700 | — | — | 1 | 9.41 |
| CHEMBL6607 | BROLAMFETAMINE | 2.0 | 1 | 9.10 |
| CHEMBL468880 | — | — | 1 | 8.64 |
| CHEMBL351858 | — | — | 1 | 8.11 |
| CHEMBL172266 | — | — | 1 | 7.03 |
| CHEMBL170735 | — | — | 1 | 5.08 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL69700 | — | Ki | = | 0.39 | nM | 9.41 |
| CHEMBL6607 | BROLAMFETAMINE | Ki | = | 0.79 | nM | 9.10 |
| CHEMBL468880 | — | Ki | = | 2.3 | nM | 8.64 |
| CHEMBL351858 | — | Ki | = | 7.7 | nM | 8.11 |
| CHEMBL172266 | — | Ki | = | 94.0 | nM | 7.03 |
| CHEMBL170735 | — | Ki | = | 8250.0 | nM | 5.08 |