Assay Detail
Binding
CHEMBL617529
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Affinity towards [3H]- ketanserin-labeled 5-hydroxytryptamine 2 receptor sites in rat cortical homogenates
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Serotonin 2 (5-HT2) receptor (CHEMBL2093870) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
N-methyl derivatives of the 5-HT2 agonist 1-(4-bromo-2,5-dimethoxyphenyl)-2-aminopropane.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 7.07 | 7.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL69700 | — | — | 1 | 7.62 |
| CHEMBL6607 | BROLAMFETAMINE | 2.0 | 1 | 7.39 |
| CHEMBL351858 | — | — | 1 | 7.10 |
| CHEMBL468880 | — | — | 1 | 6.84 |
| CHEMBL172266 | — | — | 1 | 6.42 |
| CHEMBL170735 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL69700 | — | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL6607 | BROLAMFETAMINE | Ki | = | 41.0 | nM | 7.39 |
| CHEMBL351858 | — | Ki | = | 79.0 | nM | 7.10 |
| CHEMBL468880 | — | Ki | = | 145.0 | nM | 6.84 |
| CHEMBL172266 | — | Ki | = | 380.0 | nM | 6.42 |
| CHEMBL170735 | — | Ki | > | 25000.0 | nM | - |