Assay Detail
Binding
CHEMBL617532
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Binding affinity against 5-hydroxytryptamine 2 receptor from rat frontal cortex using [125]-(R)-DOI as radioligand
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Frontal cortex |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Serotonin 2 (5-HT2) receptor (CHEMBL2093870) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
Effect of a chiral 4-alkyl substituent in hallucinogenic amphetamines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 8.04 | 8.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL263881 | LYSERGIDE | 2.0 | 1 | 8.20 |
| CHEMBL119924 | — | — | 1 | 8.11 |
| CHEMBL120116 | — | — | 1 | 8.10 |
| CHEMBL8600 | DOM | — | 1 | 7.73 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL263881 | LYSERGIDE | Ki | = | 6.31 | nM | 8.20 |
| CHEMBL119924 | — | Ki | = | 7.84 | nM | 8.11 |
| CHEMBL120116 | — | Ki | = | 7.87 | nM | 8.10 |
| CHEMBL8600 | DOM | Ki | = | 18.6 | nM | 7.73 |