Assay Detail
Binding
CHEMBL617534
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Binding affinity against 5-hydroxytryptamine 2 receptor of rat frontal cortex using [3H]ketanserin radioligand
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Frontal cortex |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Serotonin 2 (5-HT2) receptor (CHEMBL2093870) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
A structure-affinity study of the binding of 4-substituted analogues of 1-(2,5-dimethoxyphenyl)-2-aminopropane at 5-HT2 serotonin receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 27 | 6.86 | 8.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL51 | KETANSERIN | 3.0 | 1 | 8.92 |
| CHEMBL1204133 | — | — | 1 | 8.60 |
| CHEMBL1204088 | — | — | 1 | 8.52 |
| CHEMBL273770 | — | — | 1 | 8.15 |
| CHEMBL1204089 | — | — | 1 | 8.15 |
| CHEMBL1204134 | — | — | 1 | 8.00 |
| CHEMBL6616 | — | — | 1 | 7.72 |
| CHEMBL8317 | — | — | 1 | 7.72 |
| CHEMBL6607 | BROLAMFETAMINE | 2.0 | 1 | 7.39 |
| CHEMBL8214 | — | — | 1 | 7.24 |
| CHEMBL8569 | — | — | 1 | 7.16 |
| CHEMBL8237 | — | — | 1 | 7.12 |
| CHEMBL8600 | DOM | — | 1 | 7.00 |
| CHEMBL8224 | — | — | 1 | 7.00 |
| CHEMBL8100 | — | — | 1 | 6.66 |
| CHEMBL8301 | — | — | 1 | 6.52 |
| CHEMBL267526 | — | — | 1 | 5.96 |
| CHEMBL8389 | — | — | 1 | 5.90 |
| CHEMBL8126 | — | — | 1 | 5.82 |
| CHEMBL8225 | — | — | 1 | 5.66 |
| CHEMBL1204090 | — | — | 1 | 5.62 |
| CHEMBL273251 | — | — | 1 | 5.61 |
| CHEMBL8642 | — | — | 1 | 5.28 |
| CHEMBL416514 | — | — | 1 | 5.12 |
| CHEMBL8028 | — | — | 1 | 4.58 |
| CHEMBL1204087 | — | — | 1 | - |
| CHEMBL8352 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL51 | KETANSERIN | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL1204133 | — | Ki | = | 2.5 | nM | 8.60 |
| CHEMBL1204088 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL273770 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL1204089 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL1204134 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL6616 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL8317 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL6607 | BROLAMFETAMINE | Ki | = | 41.0 | nM | 7.39 |
| CHEMBL8214 | — | Ki | = | 58.0 | nM | 7.24 |
| CHEMBL8569 | — | Ki | = | 69.0 | nM | 7.16 |
| CHEMBL8237 | — | Ki | = | 76.0 | nM | 7.12 |
| CHEMBL8600 | DOM | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL8224 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL8100 | — | Ki | = | 218.0 | nM | 6.66 |
| CHEMBL8301 | — | Ki | = | 300.0 | nM | 6.52 |
| CHEMBL267526 | — | Ki | = | 1100.0 | nM | 5.96 |
| CHEMBL8389 | — | Ki | = | 1250.0 | nM | 5.90 |
| CHEMBL8126 | — | Ki | = | 1530.0 | nM | 5.82 |
| CHEMBL8225 | — | Ki | = | 2200.0 | nM | 5.66 |
| CHEMBL1204090 | — | Ki | = | 2400.0 | nM | 5.62 |
| CHEMBL273251 | — | Ki | = | 2460.0 | nM | 5.61 |
| CHEMBL8642 | — | Ki | = | 5200.0 | nM | 5.28 |
| CHEMBL416514 | — | Ki | = | 7550.0 | nM | 5.12 |
| CHEMBL8028 | — | Ki | = | 26000.0 | nM | 4.58 |
| CHEMBL1204087 | — | Ki | > | 50000.0 | nM | - |
| CHEMBL8352 | — | Ki | > | 50000.0 | nM | - |