Assay Detail
Binding
CHEMBL617535
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Binding affinity against 5-hydroxytryptamine 2 receptor using [3H]ketanserin as radioligand
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Serotonin 2 (5-HT2) receptor (CHEMBL2093870) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
Binding of indolylalkylamines at 5-HT2 serotonin receptors: examination of a hydrophobic binding region.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 14 | 6.37 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL92619 | — | — | 1 | 7.00 |
| CHEMBL428004 | — | — | 1 | 6.85 |
| CHEMBL96622 | — | — | 1 | 6.80 |
| CHEMBL96715 | — | — | 1 | 6.60 |
| CHEMBL96302 | — | — | 1 | 6.55 |
| CHEMBL8165 | 5-METHOXYTRYPTAMINE | — | 1 | 6.52 |
| CHEMBL31115 | — | — | 1 | 6.46 |
| CHEMBL439773 | — | — | 1 | 6.20 |
| CHEMBL92620 | — | — | 1 | 5.98 |
| CHEMBL328750 | — | — | 1 | 5.81 |
| CHEMBL96674 | — | — | 1 | 5.28 |
| CHEMBL30713 | — | — | 1 | - |
| CHEMBL328939 | — | — | 1 | - |
| CHEMBL554032 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL92619 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL428004 | — | Ki | = | 140.0 | nM | 6.85 |
| CHEMBL96622 | — | Ki | = | 160.0 | nM | 6.80 |
| CHEMBL96715 | — | Ki | = | 250.0 | nM | 6.60 |
| CHEMBL96302 | — | Ki | = | 280.0 | nM | 6.55 |
| CHEMBL8165 | 5-METHOXYTRYPTAMINE | Ki | = | 302.0 | nM | 6.52 |
| CHEMBL31115 | — | Ki | = | 345.0 | nM | 6.46 |
| CHEMBL439773 | — | Ki | = | 635.0 | nM | 6.20 |
| CHEMBL92620 | — | Ki | = | 1040.0 | nM | 5.98 |
| CHEMBL328750 | — | Ki | = | 1550.0 | nM | 5.81 |
| CHEMBL96674 | — | Ki | = | 5200.0 | nM | 5.28 |
| CHEMBL30713 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL328939 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL554032 | — | Ki | > | 10000.0 | nM | - |