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Assay Detail

CHEMBL617537

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity determined in radioreceptor binding assay by using [3H]ketanserin radioligand against 5-hydroxytryptamine 2 receptor
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 4 — Cell-line / Tissue
Curated By Autocuration

Target

Serotonin 2 (5-HT2) receptor (CHEMBL2093870)
Type PROTEIN FAMILY
Organism Rattus norvegicus

Publication

Pyrrole mannich bases as potential antipsychotic agents.
Scott MK, Martin GE, DiStefano DL, Fedde CL, Kukla MJ, Barrett DL, Baldy WJ, Elgin RJ, Kesslick JM, Mathiasen JR.
J Med Chem (1992) 35 : 552 -558
PubMed 1346653 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 3 8.62 9.15

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL71 CHLORPROMAZINE 4.0 1 9.15
CHEMBL42 CLOZAPINE 4.0 1 8.74
CHEMBL54 HALOPERIDOL 4.0 1 7.97

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL71 CHLORPROMAZINE Ki = 0.7 nM 9.15
CHEMBL42 CLOZAPINE Ki = 1.8 nM 8.74
CHEMBL54 HALOPERIDOL Ki = 10.6 nM 7.97