Assay Detail
Binding
CHEMBL617541
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Binding affinity for 5-hydroxytryptamine 2 receptor from striata of male Wistar rats by displacement of [3H]ketanserin
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Serotonin 2 (5-HT2) receptor (CHEMBL2093870) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
N-[[1-(2-phenylethyl)pyrrolidin-2-yl]methyl]cyclohexanecarboxamides as selective 5-HT1A receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 6.89 | 9.18 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL51 | KETANSERIN | 3.0 | 1 | 9.18 |
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 7.37 |
| CHEMBL279729 | — | — | 1 | 7.07 |
| CHEMBL356304 | — | — | 1 | 6.80 |
| CHEMBL356945 | — | — | 1 | 6.77 |
| CHEMBL82884 | — | — | 1 | 6.62 |
| CHEMBL281363 | — | — | 1 | 6.55 |
| CHEMBL283528 | — | — | 1 | 6.52 |
| CHEMBL147279 | — | — | 1 | 6.37 |
| CHEMBL149723 | — | — | 1 | 6.37 |
| CHEMBL148352 | — | — | 1 | 6.18 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL51 | KETANSERIN | Ki | = | 0.66 | nM | 9.18 |
| CHEMBL54 | HALOPERIDOL | Ki | = | 43.0 | nM | 7.37 |
| CHEMBL279729 | — | Ki | = | 86.0 | nM | 7.07 |
| CHEMBL356304 | — | Ki | = | 160.0 | nM | 6.80 |
| CHEMBL356945 | — | Ki | = | 170.0 | nM | 6.77 |
| CHEMBL82884 | — | Ki | = | 240.0 | nM | 6.62 |
| CHEMBL281363 | — | Ki | = | 280.0 | nM | 6.55 |
| CHEMBL283528 | — | Ki | = | 300.0 | nM | 6.52 |
| CHEMBL147279 | — | Ki | = | 430.0 | nM | 6.37 |
| CHEMBL149723 | — | Ki | = | 430.0 | nM | 6.37 |
| CHEMBL148352 | — | Ki | = | 660.0 | nM | 6.18 |