Assay Detail
Binding
CHEMBL617556
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was tested for its effect on 5-hydroxytryptamine 2 receptor saturation analysis
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Serotonin 2 (5-HT2) receptor (CHEMBL2093870) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
Synthesis and biological evaluation of 1-(1,2-benzisothiazol-3-yl)- and (1,2-benzisoxazol-3-yl)piperazine derivatives as potential antipsychotic agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 2 | 9.00 | 9.02 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1204189 | TIOSPIRONE HYDROCHLORIDE | -1.0 | 1 | 9.02 |
| CHEMBL422 | TRIFLUOPERAZINE | 4.0 | 1 | 8.98 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1204189 | TIOSPIRONE HYDROCHLORIDE | Kd | = | 0.963 | nM | 9.02 |
| CHEMBL422 | TRIFLUOPERAZINE | Kd | = | 1.043 | nM | 8.98 |