Assay Detail
Binding
CHEMBL617646
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro ability to displace [3H]mesulergine binding from 5-hydroxytryptamine 2C receptor from bovine choroid plexus.
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Conformationally constrained butyrophenones with mixed dopaminergic (D(2)) and serotoninergic (5-HT(2A), 5-HT(2C)) affinities: synthesis, pharmacology, 3D-QSAR, and molecular modeling of (aminoalkyl)benzo- and -thienocycloalkanones as putative atypical antipsychotics.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 6.37 | 7.06 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL554199 | — | — | 1 | 7.06 |
| CHEMBL544091 | — | — | 1 | 6.48 |
| CHEMBL542181 | — | — | 1 | 6.44 |
| CHEMBL92673 | — | — | 1 | 6.38 |
| CHEMBL545727 | — | — | 1 | 5.96 |
| CHEMBL95112 | — | — | 1 | 5.90 |
| CHEMBL544089 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL554199 | — | Ki | = | 87.1 | nM | 7.06 |
| CHEMBL544091 | — | Ki | = | 331.13 | nM | 6.48 |
| CHEMBL542181 | — | Ki | = | 363.08 | nM | 6.44 |
| CHEMBL92673 | — | Ki | = | 416.87 | nM | 6.38 |
| CHEMBL545727 | — | Ki | = | 1096.48 | nM | 5.96 |
| CHEMBL95112 | — | Ki | = | 1258.93 | nM | 5.90 |
| CHEMBL544089 | — | Ki | < | 10000.0 | nM | - |