Assay Detail
Binding
CHEMBL617647
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In vitro affinity against serotonin (5-hydroxytryptamine 2C) receptor
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Conformationally constrained butyrophenones with affinity for dopamine (D(1), D(2), D(4)) and serotonin (5-HT(2A), 5-HT(2B), 5-HT(2C)) receptors: synthesis of aminomethylbenzo[b]furanones and their evaluation as antipsychotics.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 6.24 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | 8.30 |
| CHEMBL85 | RISPERIDONE | 4.0 | 1 | 7.38 |
| CHEMBL143937 | — | — | 1 | 6.64 |
| CHEMBL141600 | — | — | 1 | 5.47 |
| CHEMBL358895 | — | — | 1 | 4.89 |
| CHEMBL143027 | — | — | 1 | 4.74 |
| CHEMBL357517 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL42 | CLOZAPINE | Ki | = | 5.012 | nM | 8.30 |
| CHEMBL85 | RISPERIDONE | Ki | = | 41.69 | nM | 7.38 |
| CHEMBL143937 | — | Ki | = | 229.09 | nM | 6.64 |
| CHEMBL141600 | — | Ki | = | 3388.44 | nM | 5.47 |
| CHEMBL358895 | — | Ki | = | 12882.5 | nM | 4.89 |
| CHEMBL143027 | — | Ki | = | 18197.01 | nM | 4.74 |
| CHEMBL357517 | — | Ki | < | 100000.0 | nM | - |