Assay Detail
Binding
CHEMBL617667
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In vitro binding affinity on 5-hydroxytryptamine 2 receptor is inhibition of binding of [125I]- I-LSD to P11 cells
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Serotonin 2 (5-HT2) receptor (CHEMBL2093870) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
18F-labeled benzamides for studying the dopamine D2 receptor with positron emission tomography.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 7.01 | 8.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2112608 | — | — | 1 | 8.51 |
| CHEMBL1169525 | — | — | 1 | 8.43 |
| CHEMBL2112607 | — | — | 1 | 7.08 |
| CHEMBL325109 | CLEBOPRIDE | 2.0 | 1 | 7.05 |
| CHEMBL124612 | — | — | 1 | 7.03 |
| CHEMBL125237 | — | — | 1 | 6.55 |
| CHEMBL340471 | — | — | 1 | 5.74 |
| CHEMBL3084912 | — | — | 1 | 5.65 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2112608 | — | Ki | = | 3.1 | nM | 8.51 |
| CHEMBL1169525 | — | Ki | = | 3.7 | nM | 8.43 |
| CHEMBL2112607 | — | Ki | = | 84.0 | nM | 7.08 |
| CHEMBL325109 | CLEBOPRIDE | Ki | = | 89.0 | nM | 7.05 |
| CHEMBL124612 | — | Ki | = | 94.0 | nM | 7.03 |
| CHEMBL125237 | — | Ki | = | 283.0 | nM | 6.55 |
| CHEMBL340471 | — | Ki | = | 1840.0 | nM | 5.74 |
| CHEMBL3084912 | — | Ki | = | 2250.0 | nM | 5.65 |