Assay Detail
Binding
CHEMBL617678
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Displacement of [3H]ketanserin from rat prefrontal cortex 5-hydroxytryptamine 2 receptor
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Prefrontal cortex |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Serotonin 2 (5-HT2) receptor (CHEMBL2093870) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
5-HT1 and 5-HT2 binding characteristics of 1-(2,5-dimethoxy-4-bromophenyl)-2-aminopropane analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 13 | 5.84 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL134519 | — | — | 1 | 8.00 |
| CHEMBL6616 | — | — | 1 | 7.46 |
| CHEMBL6607 | BROLAMFETAMINE | 2.0 | 1 | 7.20 |
| CHEMBL61002 | — | — | 1 | 6.68 |
| CHEMBL18762 | — | — | 1 | 5.71 |
| CHEMBL61355 | — | — | 1 | 5.33 |
| CHEMBL60146 | — | — | 1 | 5.31 |
| CHEMBL8642 | — | — | 1 | 5.28 |
| CHEMBL16247 | — | — | 1 | 5.11 |
| CHEMBL16451 | — | — | 1 | 5.09 |
| CHEMBL304023 | — | — | 1 | 4.59 |
| CHEMBL405 | AMPHETAMINE | 4.0 | 1 | 4.37 |
| CHEMBL60248 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL134519 | — | Ki | = | 9.9 | nM | 8.00 |
| CHEMBL6616 | — | Ki | = | 35.0 | nM | 7.46 |
| CHEMBL6607 | BROLAMFETAMINE | Ki | = | 63.0 | nM | 7.20 |
| CHEMBL61002 | — | Ki | = | 210.0 | nM | 6.68 |
| CHEMBL18762 | — | Ki | = | 1930.0 | nM | 5.71 |
| CHEMBL61355 | — | Ki | = | 4650.0 | nM | 5.33 |
| CHEMBL60146 | — | Ki | = | 4870.0 | nM | 5.31 |
| CHEMBL8642 | — | Ki | = | 5200.0 | nM | 5.28 |
| CHEMBL16247 | — | Ki | = | 7850.0 | nM | 5.11 |
| CHEMBL16451 | — | Ki | = | 8130.0 | nM | 5.09 |
| CHEMBL304023 | — | Ki | = | 25600.0 | nM | 4.59 |
| CHEMBL405 | AMPHETAMINE | Ki | = | 43000.0 | nM | 4.37 |
| CHEMBL60248 | — | Ki | > | 25000.0 | nM | - |