Assay Detail
Binding
CHEMBL617686
Review assay metadata, readout intent, target linkage, and publication context from the same page.
The compound was tested for its binding affinity towards 5-hydroxytryptamine 2 receptor by displacing [3H]ketanserin radioligand in rat cerebral cortex
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Cerebral cortex |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Serotonin 2 (5-HT2) receptor (CHEMBL2093870) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
Pyrrole mannich bases as potential antipsychotic agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 30 | 6.66 | 9.59 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL267777 | RITANSERIN | 2.0 | 1 | 9.59 |
| CHEMBL422 | TRIFLUOPERAZINE | 4.0 | 1 | 8.28 |
| CHEMBL434512 | — | — | 1 | 7.26 |
| CHEMBL152458 | — | — | 1 | 6.96 |
| CHEMBL155506 | — | — | 1 | 6.86 |
| CHEMBL49 | BUSPIRONE | 4.0 | 1 | 6.76 |
| CHEMBL347782 | — | — | 1 | 6.71 |
| CHEMBL153335 | — | — | 1 | 6.64 |
| CHEMBL348002 | — | — | 1 | 6.62 |
| CHEMBL357532 | — | — | 1 | 6.59 |
| CHEMBL346168 | — | — | 1 | 6.58 |
| CHEMBL153136 | — | — | 1 | 6.57 |
| CHEMBL348014 | — | — | 1 | 6.50 |
| CHEMBL347334 | — | — | 1 | 6.45 |
| CHEMBL345506 | — | — | 1 | 6.41 |
| CHEMBL357286 | — | — | 1 | 6.39 |
| CHEMBL348241 | — | — | 1 | 6.34 |
| CHEMBL152363 | — | — | 1 | 6.17 |
| CHEMBL424332 | — | — | 1 | 6.17 |
| CHEMBL347056 | — | — | 1 | 6.00 |
| CHEMBL152311 | — | — | 1 | 6.00 |
| CHEMBL428175 | RWJ-25730 | — | 1 | 6.00 |
| CHEMBL153219 | — | — | 1 | 6.00 |
| CHEMBL152336 | — | — | 1 | 6.00 |
| CHEMBL346459 | — | — | 1 | - |
| CHEMBL346881 | — | — | 1 | - |
| CHEMBL153490 | — | — | 1 | - |
| CHEMBL153263 | — | — | 1 | - |
| CHEMBL9666 | — | — | 1 | - |
| CHEMBL267044 | LEVOSULPIRIDE | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL267777 | RITANSERIN | Ki | = | 0.26 | nM | 9.59 |
| CHEMBL422 | TRIFLUOPERAZINE | Ki | = | 5.2 | nM | 8.28 |
| CHEMBL434512 | — | Ki | = | 55.3 | nM | 7.26 |
| CHEMBL152458 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL155506 | — | Ki | = | 137.0 | nM | 6.86 |
| CHEMBL49 | BUSPIRONE | Ki | = | 174.0 | nM | 6.76 |
| CHEMBL347782 | — | Ki | = | 196.0 | nM | 6.71 |
| CHEMBL153335 | — | Ki | = | 227.0 | nM | 6.64 |
| CHEMBL348002 | — | Ki | = | 237.0 | nM | 6.62 |
| CHEMBL357532 | — | Ki | = | 256.0 | nM | 6.59 |
| CHEMBL346168 | — | Ki | = | 260.0 | nM | 6.58 |
| CHEMBL153136 | — | Ki | = | 267.0 | nM | 6.57 |
| CHEMBL348014 | — | Ki | = | 317.0 | nM | 6.50 |
| CHEMBL347334 | — | Ki | = | 355.0 | nM | 6.45 |
| CHEMBL345506 | — | Ki | = | 386.0 | nM | 6.41 |
| CHEMBL357286 | — | Ki | = | 409.0 | nM | 6.39 |
| CHEMBL348241 | — | Ki | = | 455.0 | nM | 6.34 |
| CHEMBL152363 | — | Ki | = | 669.0 | nM | 6.17 |
| CHEMBL424332 | — | Ki | = | 669.0 | nM | 6.17 |
| CHEMBL347056 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL152311 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL428175 | RWJ-25730 | Ki | = | 1006.0 | nM | 6.00 |
| CHEMBL153219 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL152336 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL346459 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL346881 | — | Ki | > | 100.0 | nM | - |
| CHEMBL153490 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL153263 | — | Ki | > | 100.0 | nM | - |
| CHEMBL9666 | — | Ki | > | 100.0 | nM | - |
| CHEMBL267044 | LEVOSULPIRIDE | Ki | > | 1000.0 | nM | - |