Assay Detail
Binding
CHEMBL617687
Review assay metadata, readout intent, target linkage, and publication context from the same page.
The compound was tested in vitro for binding affinity towards 5-hydroxytryptamine 2 receptor by displacing [125]I-LSD radioligand
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Serotonin 2 (5-HT2) receptor (CHEMBL2093870) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
Effect of N-alkylation on the affinities of analogues of spiperone for dopamine D2 and serotonin 5-HT2 receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 21 | 8.62 | 10.02 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL135917 | — | — | 1 | 10.02 |
| CHEMBL334349 | — | — | 1 | 9.89 |
| CHEMBL136942 | — | — | 1 | 9.51 |
| CHEMBL136852 | — | — | 1 | 9.39 |
| CHEMBL267930 | SPIPERONE | 2.0 | 1 | 9.35 |
| CHEMBL267932 | MESPIPERONE | 2.0 | 1 | 9.26 |
| CHEMBL135860 | — | — | 1 | 9.17 |
| CHEMBL337149 | — | — | 1 | 9.00 |
| CHEMBL135316 | — | — | 1 | 8.96 |
| CHEMBL344399 | — | — | 1 | 8.89 |
| CHEMBL135722 | — | — | 1 | 8.72 |
| CHEMBL134400 | — | — | 1 | 8.49 |
| CHEMBL137309 | — | — | 1 | 8.36 |
| CHEMBL137648 | — | — | 1 | 8.28 |
| CHEMBL135832 | — | — | 1 | 8.02 |
| CHEMBL335606 | — | — | 1 | 7.92 |
| CHEMBL337181 | — | — | 1 | 7.85 |
| CHEMBL135500 | — | — | 1 | 7.72 |
| CHEMBL538404 | — | — | 1 | 7.68 |
| CHEMBL134545 | — | — | 1 | 7.43 |
| CHEMBL335714 | — | — | 1 | 7.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL135917 | — | Ki | = | 0.096 | nM | 10.02 |
| CHEMBL334349 | — | Ki | = | 0.13 | nM | 9.89 |
| CHEMBL136942 | — | Ki | = | 0.31 | nM | 9.51 |
| CHEMBL136852 | — | Ki | = | 0.41 | nM | 9.39 |
| CHEMBL267930 | SPIPERONE | Ki | = | 0.45 | nM | 9.35 |
| CHEMBL267932 | MESPIPERONE | Ki | = | 0.55 | nM | 9.26 |
| CHEMBL135860 | — | Ki | = | 0.68 | nM | 9.17 |
| CHEMBL337149 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL135316 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL344399 | — | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL135722 | — | Ki | = | 1.9 | nM | 8.72 |
| CHEMBL134400 | — | Ki | = | 3.2 | nM | 8.49 |
| CHEMBL137309 | — | Ki | = | 4.4 | nM | 8.36 |
| CHEMBL137648 | — | Ki | = | 5.3 | nM | 8.28 |
| CHEMBL135832 | — | Ki | = | 9.6 | nM | 8.02 |
| CHEMBL335606 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL337181 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL135500 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL538404 | — | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL134545 | — | Ki | = | 37.0 | nM | 7.43 |
| CHEMBL335714 | — | Ki | = | 89.0 | nM | 7.05 |