Assay Detail
Binding
CHEMBL617757
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Binding affinity towards human cloned 5-hydroxytryptamine 2C receptor of HEK293 cells by displacement of [3H]mesulergine
41
Total Activities
41
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | HEK293 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
1-[2-[(Heteroaryloxy)heteroaryl]carbamoyl]indolines: novel and selective 5-HT2C receptor inverse agonists with potential as antidepressant/anxiolytic agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 41 | 8.49 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL54560 | — | — | 1 | 9.40 |
| CHEMBL55207 | — | — | 1 | 9.30 |
| CHEMBL14374 | — | — | 1 | 9.20 |
| CHEMBL301012 | — | — | 1 | 9.20 |
| CHEMBL59584 | — | — | 1 | 9.10 |
| CHEMBL55079 | — | — | 1 | 9.00 |
| CHEMBL14460 | SB-243213 | — | 1 | 9.00 |
| CHEMBL14563 | SB-242084 | — | 1 | 9.00 |
| CHEMBL55331 | — | — | 1 | 9.00 |
| CHEMBL292228 | — | — | 1 | 8.90 |
| CHEMBL294030 | — | — | 1 | 8.90 |
| CHEMBL53152 | — | — | 1 | 8.90 |
| CHEMBL55292 | — | — | 1 | 8.90 |
| CHEMBL56508 | — | — | 1 | 8.80 |
| CHEMBL55472 | — | — | 1 | 8.80 |
| CHEMBL54775 | — | — | 1 | 8.80 |
| CHEMBL55964 | — | — | 1 | 8.80 |
| CHEMBL56336 | — | — | 1 | 8.80 |
| CHEMBL55792 | — | — | 1 | 8.70 |
| CHEMBL52308 | — | — | 1 | 8.70 |
| CHEMBL53308 | — | — | 1 | 8.70 |
| CHEMBL301784 | — | — | 1 | 8.70 |
| CHEMBL299938 | — | — | 1 | 8.70 |
| CHEMBL52919 | — | — | 1 | 8.60 |
| CHEMBL53113 | — | — | 1 | 8.50 |
| CHEMBL54769 | — | — | 1 | 8.50 |
| CHEMBL433060 | — | — | 1 | 8.50 |
| CHEMBL56050 | — | — | 1 | 8.50 |
| CHEMBL58765 | — | — | 1 | 8.50 |
| CHEMBL54610 | — | — | 1 | 8.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL54560 | — | Ki | = | 0.3981 | nM | 9.40 |
| CHEMBL55207 | — | Ki | = | 0.5012 | nM | 9.30 |
| CHEMBL301012 | — | Ki | = | 0.631 | nM | 9.20 |
| CHEMBL14374 | — | Ki | = | 0.631 | nM | 9.20 |
| CHEMBL59584 | — | Ki | = | 0.7943 | nM | 9.10 |
| CHEMBL55079 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL14460 | SB-243213 | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL14563 | SB-242084 | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL55331 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL53152 | — | Ki | = | 1.259 | nM | 8.90 |
| CHEMBL55292 | — | Ki | = | 1.259 | nM | 8.90 |
| CHEMBL294030 | — | Ki | = | 1.259 | nM | 8.90 |
| CHEMBL292228 | — | Ki | = | 1.259 | nM | 8.90 |
| CHEMBL56336 | — | Ki | = | 1.585 | nM | 8.80 |
| CHEMBL55964 | — | Ki | = | 1.585 | nM | 8.80 |
| CHEMBL56508 | — | Ki | = | 1.585 | nM | 8.80 |
| CHEMBL54775 | — | Ki | = | 1.585 | nM | 8.80 |
| CHEMBL55472 | — | Ki | = | 1.585 | nM | 8.80 |
| CHEMBL299938 | — | Ki | = | 1.995 | nM | 8.70 |
| CHEMBL301784 | — | Ki | = | 1.995 | nM | 8.70 |
| CHEMBL53308 | — | Ki | = | 1.995 | nM | 8.70 |
| CHEMBL55792 | — | Ki | = | 1.995 | nM | 8.70 |
| CHEMBL52308 | — | Ki | = | 1.995 | nM | 8.70 |
| CHEMBL52919 | — | Ki | = | 2.512 | nM | 8.60 |
| CHEMBL53113 | — | Ki | = | 3.162 | nM | 8.50 |
| CHEMBL54769 | — | Ki | = | 3.162 | nM | 8.50 |
| CHEMBL433060 | — | Ki | = | 3.162 | nM | 8.50 |
| CHEMBL56050 | — | Ki | = | 3.162 | nM | 8.50 |
| CHEMBL58765 | — | Ki | = | 3.162 | nM | 8.50 |
| CHEMBL54610 | — | Ki | = | 3.981 | nM | 8.40 |
| CHEMBL299726 | — | Ki | = | 3.981 | nM | 8.40 |
| CHEMBL291510 | — | Ki | = | 5.012 | nM | 8.30 |
| CHEMBL59097 | — | Ki | = | 6.31 | nM | 8.20 |
| CHEMBL299530 | — | Ki | = | 6.31 | nM | 8.20 |
| CHEMBL298696 | — | Ki | = | 15.85 | nM | 7.80 |
| CHEMBL53053 | — | Ki | = | 15.85 | nM | 7.80 |
| CHEMBL55958 | — | Ki | = | 39.81 | nM | 7.40 |
| CHEMBL56232 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL53793 | — | Ki | = | 125.89 | nM | 6.90 |
| CHEMBL299506 | — | Ki | = | 199.53 | nM | 6.70 |
| CHEMBL300232 | — | Ki | = | 199.53 | nM | 6.70 |