Assay Detail
Functional
CHEMBL617823
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonistic activity against Serotonin 5-hydroxytryptamine 3 receptor of isolated guinea pig ileum (GPI)
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Ileum |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Serotonin 3 (5-HT3) receptor (CHEMBL2094132) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Homo sapiens |
Publication
Design and synthesis of novel ligands for the 5-HT3 and the 5-HT4 receptor
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 12 | 7.18 | 8.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL143197 | — | — | 1 | 8.80 |
| CHEMBL56564 | TROPISETRON | 3.0 | 1 | 7.90 |
| CHEMBL434999 | — | — | 1 | 7.90 |
| CHEMBL142687 | — | — | 1 | 7.70 |
| CHEMBL2448558 | — | — | 1 | 7.60 |
| CHEMBL1729 | CISAPRIDE | 4.0 | 1 | 7.20 |
| CHEMBL356567 | — | — | 1 | 7.20 |
| CHEMBL356287 | — | — | 1 | 6.80 |
| CHEMBL143871 | — | — | 1 | 6.70 |
| CHEMBL337591 | — | — | 1 | 6.00 |
| CHEMBL86 | METOCLOPRAMIDE | 4.0 | 1 | 5.20 |
| CHEMBL46 | ONDANSETRON | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL143197 | — | Kd | = | 1.585 | nM | 8.80 |
| CHEMBL56564 | TROPISETRON | Kd | = | 12.59 | nM | 7.90 |
| CHEMBL434999 | — | Kd | = | 12.59 | nM | 7.90 |
| CHEMBL142687 | — | Kd | = | 19.95 | nM | 7.70 |
| CHEMBL2448558 | — | Kd | = | 25.12 | nM | 7.60 |
| CHEMBL1729 | CISAPRIDE | Kd | = | 63.1 | nM | 7.20 |
| CHEMBL356567 | — | Kd | = | 63.1 | nM | 7.20 |
| CHEMBL356287 | — | Kd | = | 158.49 | nM | 6.80 |
| CHEMBL143871 | — | Kd | = | 199.53 | nM | 6.70 |
| CHEMBL337591 | — | Kd | = | 1000.0 | nM | 6.00 |
| CHEMBL86 | METOCLOPRAMIDE | Kd | = | 6309.57 | nM | 5.20 |
| CHEMBL46 | ONDANSETRON | Kd | = | 79.43 | nM | - |