Assay Detail
Binding
CHEMBL617855
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Binding affinity towards 5-hydroxytryptamine 2C receptor
46
Total Activities
46
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Novel selective and partial agonists of 5-HT3 receptors. Part 1. Synthesis and biological evaluation of piperazinopyrrolothienopyrazines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 46 | 5.54 | 7.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL301765 | — | — | 1 | 7.46 |
| CHEMBL18772 | QUIPAZINE | 2.0 | 1 | 7.21 |
| CHEMBL68390 | — | — | 1 | 6.81 |
| CHEMBL62274 | — | — | 1 | 6.77 |
| CHEMBL65974 | — | — | 1 | 6.62 |
| CHEMBL64948 | — | — | 1 | 6.46 |
| CHEMBL65736 | — | — | 1 | 6.45 |
| CHEMBL63790 | — | — | 1 | 6.34 |
| CHEMBL261977 | — | — | 1 | 6.15 |
| CHEMBL51118 | — | — | 1 | 6.12 |
| CHEMBL294368 | — | — | 1 | 6.07 |
| CHEMBL62902 | — | — | 1 | 5.97 |
| CHEMBL63713 | — | — | 1 | 5.97 |
| CHEMBL54720 | — | — | 1 | 5.73 |
| CHEMBL65669 | — | — | 1 | 5.66 |
| CHEMBL292725 | — | — | 1 | 5.59 |
| CHEMBL302447 | — | — | 1 | 5.58 |
| CHEMBL65710 | — | — | 1 | 5.43 |
| CHEMBL302431 | — | — | 1 | 5.41 |
| CHEMBL63845 | — | — | 1 | 5.23 |
| CHEMBL418678 | — | — | 1 | 5.13 |
| CHEMBL303986 | — | — | 1 | 5.08 |
| CHEMBL65413 | — | — | 1 | 5.06 |
| CHEMBL62445 | — | — | 1 | 5.00 |
| CHEMBL62366 | — | — | 1 | 4.93 |
| CHEMBL64903 | — | — | 1 | 4.85 |
| CHEMBL62911 | — | — | 1 | 4.81 |
| CHEMBL64727 | — | — | 1 | 4.72 |
| CHEMBL64559 | — | — | 1 | 4.63 |
| CHEMBL292293 | — | — | 1 | 4.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL301765 | — | IC50 | = | 34.67 | nM | 7.46 |
| CHEMBL18772 | QUIPAZINE | IC50 | = | 61.66 | nM | 7.21 |
| CHEMBL68390 | — | IC50 | = | 154.88 | nM | 6.81 |
| CHEMBL62274 | — | IC50 | = | 169.82 | nM | 6.77 |
| CHEMBL65974 | — | IC50 | = | 239.88 | nM | 6.62 |
| CHEMBL64948 | — | IC50 | = | 346.74 | nM | 6.46 |
| CHEMBL65736 | — | IC50 | = | 354.81 | nM | 6.45 |
| CHEMBL63790 | — | IC50 | = | 457.09 | nM | 6.34 |
| CHEMBL261977 | — | IC50 | = | 707.95 | nM | 6.15 |
| CHEMBL51118 | — | IC50 | = | 758.58 | nM | 6.12 |
| CHEMBL294368 | — | IC50 | = | 851.14 | nM | 6.07 |
| CHEMBL62902 | — | IC50 | = | 1071.52 | nM | 5.97 |
| CHEMBL63713 | — | IC50 | = | 1071.52 | nM | 5.97 |
| CHEMBL54720 | — | IC50 | = | 1862.09 | nM | 5.73 |
| CHEMBL65669 | — | IC50 | = | 2187.76 | nM | 5.66 |
| CHEMBL292725 | — | IC50 | = | 2570.4 | nM | 5.59 |
| CHEMBL302447 | — | IC50 | = | 2630.27 | nM | 5.58 |
| CHEMBL65710 | — | IC50 | = | 3715.35 | nM | 5.43 |
| CHEMBL302431 | — | IC50 | = | 3890.45 | nM | 5.41 |
| CHEMBL63845 | — | IC50 | = | 5888.44 | nM | 5.23 |
| CHEMBL418678 | — | IC50 | = | 7413.1 | nM | 5.13 |
| CHEMBL303986 | — | IC50 | = | 8317.64 | nM | 5.08 |
| CHEMBL65413 | — | IC50 | = | 8709.64 | nM | 5.06 |
| CHEMBL62445 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL62366 | — | IC50 | = | 11748.98 | nM | 4.93 |
| CHEMBL64903 | — | IC50 | = | 14125.38 | nM | 4.85 |
| CHEMBL62911 | — | IC50 | = | 15488.17 | nM | 4.81 |
| CHEMBL64727 | — | IC50 | = | 19054.61 | nM | 4.72 |
| CHEMBL64559 | — | IC50 | = | 23442.29 | nM | 4.63 |
| CHEMBL292293 | — | IC50 | = | 41686.94 | nM | 4.38 |
| CHEMBL63114 | — | IC50 | = | 57543.99 | nM | 4.24 |
| CHEMBL293879 | — | IC50 | = | 61659.5 | nM | 4.21 |
| CHEMBL63905 | — | IC50 | = | 72443.6 | nM | 4.14 |
| CHEMBL27403 | — | IC50 | = | 97723.72 | nM | 4.01 |
| CHEMBL65212 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL52772 | — | IC50 | = | 1380384.26 | nM | - |
| CHEMBL63588 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL62612 | — | IC50 | = | 154881.66 | nM | - |
| CHEMBL63289 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL66310 | — | IC50 | = | 102329.3 | nM | - |
| CHEMBL66408 | — | IC50 | = | 1000000.0 | nM | - |
| CHEMBL417570 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL293219 | — | IC50 | = | 213796.21 | nM | - |
| CHEMBL302104 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL66307 | — | IC50 | = | 281838.29 | nM | - |
| CHEMBL66540 | — | IC50 | = | 467735.14 | nM | - |