Assay Detail
Binding
CHEMBL617856
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Affinity towards 5-hydroxytryptamine 2C receptor in membranes from pig choroid plexus using [3H]N-methyl-mesulergine
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Novel benzothiazolin-2-one and benzoxazin-3-one arylpiperazine derivatives with mixed 5HT1A/D2 affinity as potential atypical antipsychotics.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 6.35 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | 8.00 |
| CHEMBL59741 | — | — | 1 | 7.22 |
| CHEMBL59637 | — | — | 1 | 7.05 |
| CHEMBL292935 | — | — | 1 | 7.00 |
| CHEMBL61819 | — | — | 1 | 6.62 |
| CHEMBL60885 | — | — | 1 | 6.52 |
| CHEMBL64878 | — | — | 1 | 6.50 |
| CHEMBL60047 | — | — | 1 | 6.44 |
| CHEMBL61869 | — | — | 1 | 6.28 |
| CHEMBL294730 | — | — | 1 | 6.25 |
| CHEMBL64610 | — | — | 1 | 6.10 |
| CHEMBL304438 | — | — | 1 | 5.92 |
| CHEMBL64167 | — | — | 1 | 5.70 |
| CHEMBL60447 | — | — | 1 | 5.70 |
| CHEMBL293923 | — | — | 1 | 5.40 |
| CHEMBL64845 | — | — | 1 | 4.96 |
| CHEMBL418499 | — | — | 1 | - |
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL42 | CLOZAPINE | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL59741 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL59637 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL292935 | — | IC50 | = | 99.0 | nM | 7.00 |
| CHEMBL61819 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL60885 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL64878 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL60047 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL61869 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL294730 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL64610 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL304438 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL64167 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL60447 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL293923 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL64845 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL418499 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL54 | HALOPERIDOL | IC50 | > | 10000.0 | nM | - |