Assay Detail
Binding
CHEMBL617862
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding activity against 5-hydroxytryptamine 2C receptor from pig cortex membrane using [3H]mesulergine as radioligand.
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis and serotonergic activity of N,N-dimethyl-2-[5-(1,2,4-triazol-1-ylmethyl)-1H-indol-3-yl]ethylamine and analogues: potent agonists for 5-HT1D receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 5.58 | 6.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL54265 | — | — | 1 | 6.30 |
| CHEMBL53467 | — | — | 1 | 6.00 |
| CHEMBL39243 | — | — | 1 | 5.90 |
| CHEMBL53485 | — | — | 1 | 5.70 |
| CHEMBL299213 | — | — | 1 | 5.60 |
| CHEMBL298544 | — | — | 1 | 5.60 |
| CHEMBL53764 | — | — | 1 | 5.50 |
| CHEMBL53349 | — | — | 1 | 5.50 |
| CHEMBL52912 | — | — | 1 | 5.40 |
| CHEMBL53128 | — | — | 1 | 5.30 |
| CHEMBL54103 | — | — | 1 | 5.10 |
| CHEMBL905 | RIZATRIPTAN | 4.0 | 1 | 5.10 |
| CHEMBL300209 | — | — | 1 | - |
| CHEMBL52264 | — | — | 1 | - |
| CHEMBL50834 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL54265 | — | IC50 | = | 501.19 | nM | 6.30 |
| CHEMBL53467 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL39243 | — | IC50 | = | 1258.93 | nM | 5.90 |
| CHEMBL53485 | — | IC50 | = | 1995.26 | nM | 5.70 |
| CHEMBL299213 | — | IC50 | = | 2511.89 | nM | 5.60 |
| CHEMBL298544 | — | IC50 | = | 2511.89 | nM | 5.60 |
| CHEMBL53764 | — | IC50 | = | 3162.28 | nM | 5.50 |
| CHEMBL53349 | — | IC50 | = | 3162.28 | nM | 5.50 |
| CHEMBL52912 | — | IC50 | = | 3981.07 | nM | 5.40 |
| CHEMBL53128 | — | IC50 | = | 5011.87 | nM | 5.30 |
| CHEMBL54103 | — | IC50 | = | 7943.28 | nM | 5.10 |
| CHEMBL905 | RIZATRIPTAN | IC50 | = | 7943.28 | nM | 5.10 |
| CHEMBL300209 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL52264 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL50834 | — | IC50 | > | 10000.0 | nM | - |