Assay Detail
Functional
CHEMBL617882
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonistic activity for 5-HT2c (5-HT2C) by measuring [3H]inositol monophosphate fromation in CHO cells in which the human 5-HT2C receptor subtype was stably expressed
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis and 5-hydroxytryptamine (5-HT) activity of 2,3,4,4a-tetrahydro-1H-pyrazino[1,2-a]quinoxalin-5-(6H)ones and 2,3,4,4a,5,6-hexahydro-1H-pyrazino[1,2-a]quinoxalines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 11 | 7.30 | 8.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL58009 | — | — | 1 | 8.12 |
| CHEMBL303516 | — | — | 1 | 8.10 |
| CHEMBL301466 | — | — | 1 | 7.92 |
| CHEMBL60280 | — | — | 1 | 7.72 |
| CHEMBL305123 | — | — | 1 | 7.72 |
| CHEMBL61695 | — | — | 1 | 7.35 |
| CHEMBL291794 | — | — | 1 | 7.31 |
| CHEMBL59631 | — | — | 1 | 7.07 |
| CHEMBL304013 | — | — | 1 | 6.87 |
| CHEMBL60830 | — | — | 1 | 6.54 |
| CHEMBL59619 | — | — | 1 | 5.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL58009 | — | EC50 | = | 7.6 | nM | 8.12 |
| CHEMBL303516 | — | EC50 | = | 8.0 | nM | 8.10 |
| CHEMBL301466 | — | EC50 | = | 12.0 | nM | 7.92 |
| CHEMBL60280 | — | EC50 | = | 19.0 | nM | 7.72 |
| CHEMBL305123 | — | EC50 | = | 19.0 | nM | 7.72 |
| CHEMBL61695 | — | EC50 | = | 45.0 | nM | 7.35 |
| CHEMBL291794 | — | EC50 | = | 49.0 | nM | 7.31 |
| CHEMBL59631 | — | EC50 | = | 86.0 | nM | 7.07 |
| CHEMBL304013 | — | EC50 | = | 136.0 | nM | 6.87 |
| CHEMBL60830 | — | EC50 | = | 290.0 | nM | 6.54 |
| CHEMBL59619 | — | EC50 | = | 2600.0 | nM | 5.58 |