Assay Detail
Binding
CHEMBL617894
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Ability to displace [3H]- mesulergine from human cloned 5-hydroxytryptamine 2C receptor expressed in CHO cells
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis and structure-activity relationship of 2-(aminoalkyl)-3,3a,8,12b-tetrahydro-2H-dibenzocyclohepta[1,2-b]furan derivatives: a novel series of 5-HT(2A/2C) receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 22 | 7.51 | 9.03 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL329566 | — | — | 1 | 9.03 |
| CHEMBL328573 | — | — | 1 | 9.00 |
| CHEMBL329268 | — | — | 1 | 8.49 |
| CHEMBL92667 | — | — | 1 | 8.17 |
| CHEMBL329685 | — | — | 1 | 8.01 |
| CHEMBL328356 | — | — | 1 | 7.89 |
| CHEMBL2112371 | — | — | 1 | 7.80 |
| CHEMBL328662 | — | — | 1 | 7.77 |
| CHEMBL327306 | — | — | 1 | 7.61 |
| CHEMBL96429 | — | — | 1 | 7.57 |
| CHEMBL327651 | — | — | 1 | 7.55 |
| CHEMBL96158 | — | — | 1 | 7.51 |
| CHEMBL93321 | — | — | 1 | 7.49 |
| CHEMBL96471 | — | — | 1 | 7.37 |
| CHEMBL92333 | — | — | 1 | 6.97 |
| CHEMBL316068 | — | — | 1 | 6.92 |
| CHEMBL328209 | — | — | 1 | 6.91 |
| CHEMBL96732 | — | — | 1 | 6.78 |
| CHEMBL92337 | — | — | 1 | 6.77 |
| CHEMBL330713 | — | — | 1 | 6.74 |
| CHEMBL314968 | — | — | 1 | 6.62 |
| CHEMBL318659 | — | — | 1 | 6.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL329566 | — | Ki | = | 0.93 | nM | 9.03 |
| CHEMBL328573 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL329268 | — | Ki | = | 3.25 | nM | 8.49 |
| CHEMBL92667 | — | Ki | = | 6.7 | nM | 8.17 |
| CHEMBL329685 | — | Ki | = | 9.7 | nM | 8.01 |
| CHEMBL328356 | — | Ki | = | 12.9 | nM | 7.89 |
| CHEMBL2112371 | — | Ki | = | 15.9 | nM | 7.80 |
| CHEMBL328662 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL327306 | — | Ki | = | 24.7 | nM | 7.61 |
| CHEMBL96429 | — | Ki | = | 27.0 | nM | 7.57 |
| CHEMBL327651 | — | Ki | = | 28.0 | nM | 7.55 |
| CHEMBL96158 | — | Ki | = | 31.0 | nM | 7.51 |
| CHEMBL93321 | — | Ki | = | 32.5 | nM | 7.49 |
| CHEMBL96471 | — | Ki | = | 42.7 | nM | 7.37 |
| CHEMBL92333 | — | Ki | = | 107.4 | nM | 6.97 |
| CHEMBL316068 | — | Ki | = | 120.0 | nM | 6.92 |
| CHEMBL328209 | — | Ki | = | 123.5 | nM | 6.91 |
| CHEMBL96732 | — | Ki | = | 166.0 | nM | 6.78 |
| CHEMBL92337 | — | Ki | = | 170.0 | nM | 6.77 |
| CHEMBL330713 | — | Ki | = | 183.0 | nM | 6.74 |
| CHEMBL314968 | — | Ki | = | 239.0 | nM | 6.62 |
| CHEMBL318659 | — | Ki | = | 677.0 | nM | 6.17 |