Assay Detail
Binding
CHEMBL617970
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Potency at neuronal 5-hydroxytryptamine 3 receptor in the rabbit heart
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Oryctolagus cuniculus |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Serotonin 3 (5-HT3) receptor (CHEMBL2094132) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Homo sapiens |
Publication
Conformation-activity relationship study of 5-HT3 receptor antagonists and a definition of a model for this receptor site.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 7 | 9.00 | 10.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL289469 | GRANISETRON | 4.0 | 1 | 10.70 |
| CHEMBL46 | ONDANSETRON | 4.0 | 1 | 10.10 |
| CHEMBL2107804 | BEMESETRON | 2.0 | 1 | 9.30 |
| CHEMBL40883 | — | — | 1 | 9.00 |
| CHEMBL301281 | — | — | 1 | 7.70 |
| CHEMBL1947052 | — | — | 1 | 7.20 |
| CHEMBL56564 | TROPISETRON | 3.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL289469 | GRANISETRON | Kd | = | 0.01995 | nM | 10.70 |
| CHEMBL46 | ONDANSETRON | Kd | = | 0.07943 | nM | 10.10 |
| CHEMBL2107804 | BEMESETRON | Kd | = | 0.5012 | nM | 9.30 |
| CHEMBL40883 | — | Kd | = | 1.0 | nM | 9.00 |
| CHEMBL301281 | — | Kd | = | 19.95 | nM | 7.70 |
| CHEMBL1947052 | — | Kd | = | 63.1 | nM | 7.20 |
| CHEMBL56564 | TROPISETRON | Kd | = | 106.0 | nM | - |