Assay Detail
Binding
CHEMBL617971
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Potency at neuronal 5-hydroxytryptamine 3 receptors in the rabbit heart
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Oryctolagus cuniculus |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Serotonin 3 (5-HT3) receptor (CHEMBL2094132) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Homo sapiens |
Publication
Conformation-activity relationship study of 5-HT3 receptor antagonists and a definition of a model for this receptor site.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 5 | 8.70 | 9.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL40935 | — | — | 1 | 9.80 |
| CHEMBL40324 | — | — | 1 | 9.20 |
| CHEMBL2448558 | — | — | 1 | 8.90 |
| CHEMBL40480 | — | — | 1 | 8.30 |
| CHEMBL86 | METOCLOPRAMIDE | 4.0 | 1 | 7.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL40935 | — | Kd | = | 0.1585 | nM | 9.80 |
| CHEMBL40324 | — | Kd | = | 0.631 | nM | 9.20 |
| CHEMBL2448558 | — | Kd | = | 1.259 | nM | 8.90 |
| CHEMBL40480 | — | Kd | = | 5.012 | nM | 8.30 |
| CHEMBL86 | METOCLOPRAMIDE | Kd | = | 50.12 | nM | 7.30 |