Assay Detail
Functional
CHEMBL617976
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Evaluated for the antagonistic activity against Serotonin 5-hydroxytryptamine 3 receptor in isolated perfused rabbit heart (RH)
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Oryctolagus cuniculus |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Serotonin 3 (5-HT3) receptor (CHEMBL2094132) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Homo sapiens |
Publication
Design and synthesis of novel ligands for the 5-HT3 and the 5-HT4 receptor
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 5 | 8.70 | 10.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL56564 | TROPISETRON | 3.0 | 1 | 10.60 |
| CHEMBL46 | ONDANSETRON | 4.0 | 1 | 10.10 |
| CHEMBL2448558 | — | — | 1 | 8.60 |
| CHEMBL1729 | CISAPRIDE | 4.0 | 1 | 7.10 |
| CHEMBL86 | METOCLOPRAMIDE | 4.0 | 1 | 7.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL56564 | TROPISETRON | Kd | = | 0.02512 | nM | 10.60 |
| CHEMBL46 | ONDANSETRON | Kd | = | 0.07943 | nM | 10.10 |
| CHEMBL2448558 | — | Kd | = | 2.512 | nM | 8.60 |
| CHEMBL1729 | CISAPRIDE | Kd | = | 79.43 | nM | 7.10 |
| CHEMBL86 | METOCLOPRAMIDE | Kd | = | 79.43 | nM | 7.10 |