Assay Detail
Binding
CHEMBL618006
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Inhibition of human neutrophil 5-lipoxygenase
65
Total Activities
65
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Polyunsaturated fatty acid 5-lipoxygenase (CHEMBL215) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Effect of structure on potency and selectivity in 2,6-disubstituted 4-(2-arylethenyl)phenol lipoxygenase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 65 | 6.63 | 7.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL58979 | — | — | 1 | 7.35 |
| CHEMBL56798 | — | — | 1 | 7.27 |
| CHEMBL56833 | — | — | 1 | 7.19 |
| CHEMBL434783 | — | — | 1 | 7.07 |
| CHEMBL413324 | — | — | 1 | 7.07 |
| CHEMBL293825 | — | — | 1 | 7.05 |
| CHEMBL54221 | — | — | 1 | 7.04 |
| CHEMBL300159 | — | — | 1 | 7.00 |
| CHEMBL55960 | — | — | 1 | 7.00 |
| CHEMBL57358 | ENOFELAST | 2.0 | 1 | 6.92 |
| CHEMBL56461 | — | — | 1 | 6.89 |
| CHEMBL417379 | — | — | 1 | 6.77 |
| CHEMBL8842 | — | — | 1 | 6.70 |
| CHEMBL56576 | — | — | 1 | 6.62 |
| CHEMBL291710 | — | — | 1 | 6.54 |
| CHEMBL55217 | — | — | 1 | 6.43 |
| CHEMBL56009 | — | — | 1 | 6.37 |
| CHEMBL56551 | — | — | 1 | 6.23 |
| CHEMBL293821 | — | — | 1 | 6.00 |
| CHEMBL8562 | — | — | 1 | 5.96 |
| CHEMBL266100 | — | — | 1 | 5.92 |
| CHEMBL414824 | — | — | 1 | 5.77 |
| CHEMBL8846 | PRIFELONE | 2.0 | 1 | 5.32 |
| CHEMBL299048 | — | — | 1 | - |
| CHEMBL55448 | — | — | 1 | - |
| CHEMBL8813 | — | — | 1 | - |
| CHEMBL55435 | — | — | 1 | - |
| CHEMBL56283 | — | — | 1 | - |
| CHEMBL293755 | — | — | 1 | - |
| CHEMBL293150 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL58979 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL56798 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL56833 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL434783 | — | IC50 | = | 86.0 | nM | 7.07 |
| CHEMBL413324 | — | IC50 | = | 86.0 | nM | 7.07 |
| CHEMBL293825 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL54221 | — | IC50 | = | 91.0 | nM | 7.04 |
| CHEMBL300159 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL55960 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL57358 | ENOFELAST | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL56461 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL417379 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL8842 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL56576 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL291710 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL55217 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL56009 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL56551 | — | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL293821 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL8562 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL266100 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL414824 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL8846 | PRIFELONE | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL8959 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL300976 | — | IC50 | ~ | 100.0 | nM | - |
| CHEMBL58929 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL57298 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL440480 | — | IC50 | < | 1000.0 | nM | - |
| CHEMBL56460 | — | IC50 | < | 1000.0 | nM | - |
| CHEMBL280018 | — | IC50 | ~ | 100.0 | nM | - |
| CHEMBL59198 | — | IC50 | < | 1000.0 | nM | - |
| CHEMBL58990 | — | IC50 | < | 1000.0 | nM | - |
| CHEMBL56196 | — | IC50 | < | 1000.0 | nM | - |
| CHEMBL54226 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL292136 | — | IC50 | < | 1000.0 | nM | - |
| CHEMBL57016 | — | IC50 | < | 1000.0 | nM | - |
| CHEMBL54169 | — | IC50 | < | 1000.0 | nM | - |
| CHEMBL442167 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL294003 | — | IC50 | < | 1000.0 | nM | - |
| CHEMBL55293 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL301304 | — | IC50 | < | 1000.0 | nM | - |
| CHEMBL56365 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL56422 | — | IC50 | < | 1000.0 | nM | - |
| CHEMBL293150 | — | IC50 | < | 1000.0 | nM | - |
| CHEMBL293755 | — | IC50 | < | 1000.0 | nM | - |
| CHEMBL56283 | — | IC50 | < | 1000.0 | nM | - |
| CHEMBL55435 | — | IC50 | < | 1000.0 | nM | - |
| CHEMBL8813 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL55448 | — | IC50 | < | 1000.0 | nM | - |
| CHEMBL299048 | — | IC50 | < | 1000.0 | nM | - |