Assay Detail
Binding
CHEMBL618017
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Inhibition of Human 5-lipoxygenase
23
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Polyunsaturated fatty acid 5-lipoxygenase (CHEMBL215) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Thiopyranol[2,3,4-c,d]indoles as inhibitors of 5-lipoxygenase, 5-lipoxygenase-activating protein, and leukotriene C4 synthase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 7.26 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL140915 | — | — | 3 | 8.00 |
| CHEMBL275634 | — | — | 1 | 7.66 |
| CHEMBL141645 | — | — | 1 | 7.64 |
| CHEMBL341562 | — | — | 1 | 7.58 |
| CHEMBL342680 | — | — | 1 | 7.52 |
| CHEMBL337576 | — | — | 1 | 7.52 |
| CHEMBL140204 | — | — | 1 | 7.40 |
| CHEMBL415530 | — | — | 1 | 7.28 |
| CHEMBL138551 | — | — | 1 | 7.26 |
| CHEMBL341948 | — | — | 1 | 7.22 |
| CHEMBL437444 | — | — | 1 | 7.22 |
| CHEMBL342684 | — | — | 1 | 7.22 |
| CHEMBL410493 | — | — | 1 | 7.21 |
| CHEMBL140157 | — | — | 1 | 7.16 |
| CHEMBL139891 | — | — | 1 | 7.00 |
| CHEMBL142032 | — | — | 1 | 6.89 |
| CHEMBL341785 | — | — | 1 | 6.77 |
| CHEMBL341696 | — | — | 1 | 6.76 |
| CHEMBL344636 | — | — | 1 | 6.44 |
| CHEMBL29097 | — | — | 1 | - |
| CHEMBL16596 | QUIFLAPON | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL140915 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL140915 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL275634 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL141645 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL341562 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL342680 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL337576 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL140204 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL415530 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL138551 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL341948 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL437444 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL342684 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL410493 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL140157 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL140915 | — | IC50 | = | 95.0 | nM | 7.02 |
| CHEMBL139891 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL142032 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL341785 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL341696 | — | IC50 | = | 175.0 | nM | 6.76 |
| CHEMBL344636 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL29097 | — | IC50 | > | 10.0 | nM | - |
| CHEMBL16596 | QUIFLAPON | IC50 | > | 10000.0 | nM | - |