Assay Detail
Binding
CHEMBL618018
Review assay metadata, readout intent, target linkage, and publication context from the same page.
The compound was evaluated for its inhibitory activity against 5-lipoxygenase using granulocytes-type cells
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Polyunsaturated fatty acid 5-lipoxygenase (CHEMBL215) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and activity of a new methoxytetrahydropyran derivative as dual cyclooxygenase-2/5-lipoxygenase inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.92 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL423638 | — | — | 1 | 8.52 |
| CHEMBL93 | ZILEUTON | 4.0 | 1 | 5.54 |
| CHEMBL165946 | — | — | 1 | 5.22 |
| CHEMBL349518 | — | — | 1 | 4.40 |
| CHEMBL122 | ROFECOXIB | 4.0 | 1 | - |
| CHEMBL7162 | NS-398 | — | 1 | - |
| CHEMBL166156 | — | — | 1 | - |
| CHEMBL164393 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL423638 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL93 | ZILEUTON | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL165946 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL349518 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL122 | ROFECOXIB | IC50 | > | 10000.0 | nM | - |
| CHEMBL7162 | NS-398 | IC50 | > | 10000.0 | nM | - |
| CHEMBL166156 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL164393 | — | IC50 | > | 10000.0 | nM | - |