Assay Detail
Binding
CHEMBL618020
Review assay metadata, readout intent, target linkage, and publication context from the same page.
The compound was tested for the concentration (in uM) to inhibit 50% of 5-Lipoxygenase (5-LOX) and is expressed in IC50.
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Polyunsaturated fatty acid 5-lipoxygenase (CHEMBL215) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
New cyclooxygenase-2/5-lipoxygenase inhibitors. 1. 7-tert-buty1-2,3-dihydro-3,3-dimethylbenzofuran derivatives as gastrointestinal safe antiinflammatory and analgesic agents: discovery and variation of the 5-keto substituent.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.13 | 5.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL13878 | TEBUFELONE | 2.0 | 1 | 5.52 |
| CHEMBL275120 | — | — | 1 | 5.30 |
| CHEMBL13920 | — | — | 1 | 5.22 |
| CHEMBL14420 | — | — | 1 | 5.10 |
| CHEMBL13623 | — | — | 1 | 5.10 |
| CHEMBL13980 | — | — | 1 | 5.07 |
| CHEMBL13661 | — | — | 1 | 4.92 |
| CHEMBL276436 | — | — | 1 | 4.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL13878 | TEBUFELONE | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL275120 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL13920 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL14420 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL13623 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL13980 | — | IC50 | = | 8500.0 | nM | 5.07 |
| CHEMBL13661 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL276436 | — | IC50 | = | 15000.0 | nM | 4.82 |