Assay Detail
Binding
CHEMBL618082
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Binding affinity against 5-hydroxytryptamine 5A receptor in HEK 293 cells was determined using [3H]LSD as radioligand
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | HEK293 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
5-hydroxytryptamine receptor 5A (CHEMBL4655) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
N-Arylsulfonylindole derivatives as serotonin 5-HT(6) receptor ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 5.59 | 5.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL125745 | — | — | 1 | 5.92 |
| CHEMBL126340 | — | — | 1 | 5.80 |
| CHEMBL92139 | — | — | 1 | 5.47 |
| CHEMBL93868 | — | — | 1 | 5.40 |
| CHEMBL263700 | — | — | 1 | 5.35 |
| CHEMBL76237 | — | — | 1 | - |
| CHEMBL127411 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL125745 | — | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL126340 | — | Ki | = | 1600.0 | nM | 5.80 |
| CHEMBL92139 | — | Ki | = | 3400.0 | nM | 5.47 |
| CHEMBL93868 | — | Ki | = | 4000.0 | nM | 5.40 |
| CHEMBL263700 | — | Ki | = | 4500.0 | nM | 5.35 |
| CHEMBL76237 | — | Ki | > | 5000.0 | nM | - |
| CHEMBL127411 | — | Ki | > | 6400.0 | nM | - |