Assay Detail
Binding
CHEMBL618090
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human 5-hydroxytryptamine 6 receptor
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
From hit to lead. Analyzing structure-profile relationships.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.82 | 6.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL116463 | — | — | 1 | 6.37 |
| CHEMBL113956 | — | — | 1 | 6.10 |
| CHEMBL116735 | — | — | 1 | 5.87 |
| CHEMBL325516 | — | — | 1 | 5.82 |
| CHEMBL326263 | — | — | 1 | 5.64 |
| CHEMBL117537 | — | — | 1 | 5.11 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL116463 | — | IC50 | = | 427.0 | nM | 6.37 |
| CHEMBL113956 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL116735 | — | IC50 | = | 1350.0 | nM | 5.87 |
| CHEMBL325516 | — | IC50 | = | 1530.0 | nM | 5.82 |
| CHEMBL326263 | — | IC50 | = | 2280.0 | nM | 5.64 |
| CHEMBL117537 | — | IC50 | = | 7780.0 | nM | 5.11 |