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Assay Detail

CHEMBL618100

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Binding
Inhibitory activity against 5-lipoxygenase
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Cavia porcellus
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Polyunsaturated fatty acid 5-lipoxygenase (CHEMBL215)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Synthesis and 5-lipoxygenase inhibitory activities of eicosanoid compounds.
Arai Y, Shimoji K, Konno M, Konishi Y, Okuyama S, Iguchi S, Hayashi M, Miyamoto T, Toda M.
J Med Chem (1983) 26 : 72 -78
PubMed 6298421 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 10 4.88 5.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL69439 LEUKOTRIENE A4 1 5.70
CHEMBL164813 1 5.70
CHEMBL349755 1 5.70
CHEMBL163838 1 5.52
CHEMBL165682 1 4.70
CHEMBL423092 1 4.70
CHEMBL165420 1 4.55
CHEMBL348933 1 4.19
CHEMBL164332 1 4.00
CHEMBL17775 1 4.00

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL69439 LEUKOTRIENE A4 IC50 = 2000.0 nM 5.70
CHEMBL164813 IC50 = 2000.0 nM 5.70
CHEMBL349755 IC50 = 2000.0 nM 5.70
CHEMBL163838 IC50 = 3000.0 nM 5.52
CHEMBL165682 IC50 = 20000.0 nM 4.70
CHEMBL423092 IC50 = 20000.0 nM 4.70
CHEMBL165420 IC50 = 28000.0 nM 4.55
CHEMBL348933 IC50 = 65000.0 nM 4.19
CHEMBL164332 IC50 = 100000.0 nM 4.00
CHEMBL17775 IC50 = 100000.0 nM 4.00