Assay Detail
Binding
CHEMBL618101
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against 5-lipoxygenase in guinea pig leukocyte
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Polyunsaturated fatty acid 5-lipoxygenase (CHEMBL215) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Acrylamide derivatives as antiallergic agents. 2. Synthesis and structure-activity relationships of N-[4-[4-(diphenylmethyl)-1-piperazinyl]butyl]-3-(3-pyridyl)acryl amides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.05 | 5.31 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL154139 | TAGORIZINE | 2.0 | 1 | 5.31 |
| CHEMBL145 | CAFFEIC ACID | 3.0 | 1 | 4.78 |
| CHEMBL534 | KETOTIFEN | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL154139 | TAGORIZINE | IC50 | = | 4860.0 | nM | 5.31 |
| CHEMBL145 | CAFFEIC ACID | IC50 | = | 16700.0 | nM | 4.78 |
| CHEMBL534 | KETOTIFEN | IC50 | > | 100000.0 | nM | - |