Assay Detail
Binding
CHEMBL618103
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against partially-purified Guinea pig PMN 5-lipoxygenase
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Polyunsaturated fatty acid 5-lipoxygenase (CHEMBL215) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis, structure-activity relationships, and pharmacological evaluation of pyrrolo[3,2,1-ij]quinoline derivatives: potent histamine and platelet activating factor antagonism and 5-lipoxygenase inhibitory properties. Potential therapeutic application in asthma.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.63 | 5.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL93 | ZILEUTON | 4.0 | 1 | 5.70 |
| CHEMBL159099 | — | — | 1 | 5.55 |
| CHEMBL158583 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL93 | ZILEUTON | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL159099 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL158583 | — | IC50 | 900.0 | nM | - |