Assay Detail
Binding
CHEMBL618118
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Binding affinity towards human 5-hydroxytryptamine 6 receptor was evaluated using [3H]-LSD as radioligand
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Higher-end serotonin receptors: 5-HT(5), 5-HT(6), and 5-HT(7).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 6.68 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL93240 | METITEPINE | 2.0 | 1 | 9.40 |
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | 8.02 |
| CHEMBL6437 | MIANSERIN | 4.0 | 1 | 7.26 |
| CHEMBL39 | SEROTONIN | 3.0 | 1 | 7.19 |
| CHEMBL13816 | — | — | 1 | 6.40 |
| CHEMBL18840 | — | — | 1 | 6.14 |
| CHEMBL267930 | SPIPERONE | 2.0 | 1 | 5.80 |
| CHEMBL96729 | — | — | 1 | 5.58 |
| CHEMBL51 | KETANSERIN | 3.0 | 1 | 5.55 |
| CHEMBL18772 | QUIPAZINE | 2.0 | 1 | 5.44 |
| CHEMBL56 | 8-OH-DPAT | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL93240 | METITEPINE | Ki | = | 0.4 | nM | 9.40 |
| CHEMBL42 | CLOZAPINE | Ki | = | 9.5 | nM | 8.02 |
| CHEMBL6437 | MIANSERIN | Ki | = | 55.0 | nM | 7.26 |
| CHEMBL39 | SEROTONIN | Ki | = | 65.0 | nM | 7.19 |
| CHEMBL13816 | — | Ki | = | 400.0 | nM | 6.40 |
| CHEMBL18840 | — | Ki | = | 720.0 | nM | 6.14 |
| CHEMBL267930 | SPIPERONE | Ki | = | 1595.0 | nM | 5.80 |
| CHEMBL96729 | — | Ki | = | 2600.0 | nM | 5.58 |
| CHEMBL51 | KETANSERIN | Ki | = | 2800.0 | nM | 5.55 |
| CHEMBL18772 | QUIPAZINE | Ki | = | 3600.0 | nM | 5.44 |
| CHEMBL56 | 8-OH-DPAT | Ki | > | 10000.0 | nM | - |