Assay Detail
Binding
CHEMBL618122
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Binding affinity for human 5-hydroxytryptamine 6 receptor expressed in HEK 293 human embryonic kidney cells, [3H]-lysergic acid diethylamide as radioligand
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | HEK293 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
2-Substituted tryptamines: agents with selectivity for 5-HT(6) serotonin receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 17 | 6.86 | 7.34 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL266591 | — | — | 1 | 7.34 |
| CHEMBL267615 | — | — | 1 | 7.28 |
| CHEMBL7318 | — | — | 1 | 7.27 |
| CHEMBL39 | SEROTONIN | 3.0 | 1 | 7.12 |
| CHEMBL7257 | MEBUFOTENIN | 2.0 | 1 | 7.11 |
| CHEMBL7143 | — | — | 1 | 7.10 |
| CHEMBL8165 | 5-METHOXYTRYPTAMINE | — | 1 | 7.06 |
| CHEMBL268800 | — | — | 1 | 7.01 |
| CHEMBL7173 | — | — | 1 | 6.89 |
| CHEMBL7228 | — | — | 1 | 6.78 |
| CHEMBL6640 | TRYPTAMINE | — | 1 | 6.75 |
| CHEMBL7379 | — | — | 1 | 6.73 |
| CHEMBL7732 | — | — | 1 | 6.70 |
| CHEMBL7166 | — | — | 1 | 6.62 |
| CHEMBL7580 | — | — | 1 | 6.52 |
| CHEMBL7220 | — | — | 1 | 6.29 |
| CHEMBL7172 | — | — | 1 | 5.99 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL266591 | — | Ki | = | 46.0 | nM | 7.34 |
| CHEMBL267615 | — | Ki | = | 52.0 | nM | 7.28 |
| CHEMBL7318 | — | Ki | = | 54.0 | nM | 7.27 |
| CHEMBL39 | SEROTONIN | Ki | = | 75.0 | nM | 7.12 |
| CHEMBL7257 | MEBUFOTENIN | Ki | = | 78.0 | nM | 7.11 |
| CHEMBL7143 | — | Ki | = | 80.0 | nM | 7.10 |
| CHEMBL8165 | 5-METHOXYTRYPTAMINE | Ki | = | 88.0 | nM | 7.06 |
| CHEMBL268800 | — | Ki | = | 98.0 | nM | 7.01 |
| CHEMBL7173 | — | Ki | = | 130.0 | nM | 6.89 |
| CHEMBL7228 | — | Ki | = | 168.0 | nM | 6.78 |
| CHEMBL6640 | TRYPTAMINE | Ki | = | 180.0 | nM | 6.75 |
| CHEMBL7379 | — | Ki | = | 185.0 | nM | 6.73 |
| CHEMBL7732 | — | Ki | = | 200.0 | nM | 6.70 |
| CHEMBL7166 | — | Ki | = | 240.0 | nM | 6.62 |
| CHEMBL7580 | — | Ki | = | 300.0 | nM | 6.52 |
| CHEMBL7220 | — | Ki | = | 510.0 | nM | 6.29 |
| CHEMBL7172 | — | Ki | = | 1030.0 | nM | 5.99 |