Assay Detail
Binding
CHEMBL618126
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Displacement of [3H]LSD from human 5-hydroxytryptamine 6 receptor expressed in HEK 293 cells
14
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
6-Bicyclopiperazinyl-1-arylsulfonylindoles and 6-bicyclopiperidinyl-1-arylsulfonylindoles derivatives as novel, potent, and selective 5-HT6 receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 14 | 8.58 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL46187 | — | — | 1 | 9.70 |
| CHEMBL299822 | — | — | 2 | 9.22 |
| CHEMBL416638 | — | — | 1 | 8.89 |
| CHEMBL431298 | — | — | 1 | 8.89 |
| CHEMBL298274 | — | — | 1 | 8.77 |
| CHEMBL45977 | — | — | 1 | 8.52 |
| CHEMBL47691 | — | — | 1 | 8.48 |
| CHEMBL49598 | — | — | 1 | 8.44 |
| CHEMBL45987 | — | — | 1 | 8.33 |
| CHEMBL299569 | — | — | 1 | 8.31 |
| CHEMBL45695 | — | — | 1 | 8.24 |
| CHEMBL46071 | — | — | 1 | 7.90 |
| CHEMBL433461 | — | — | 1 | 7.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL46187 | — | Ki | = | 0.2 | nM | 9.70 |
| CHEMBL299822 | — | Ki | = | 0.6 | nM | 9.22 |
| CHEMBL299822 | — | Ki | = | 0.8 | nM | 9.10 |
| CHEMBL416638 | — | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL431298 | — | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL298274 | — | Ki | = | 1.7 | nM | 8.77 |
| CHEMBL45977 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL47691 | — | Ki | = | 3.3 | nM | 8.48 |
| CHEMBL49598 | — | Ki | = | 3.6 | nM | 8.44 |
| CHEMBL45987 | — | Ki | = | 4.7 | nM | 8.33 |
| CHEMBL299569 | — | Ki | = | 4.9 | nM | 8.31 |
| CHEMBL45695 | — | Ki | = | 5.7 | nM | 8.24 |
| CHEMBL46071 | — | Ki | = | 12.6 | nM | 7.90 |
| CHEMBL433461 | — | Ki | = | 50.0 | nM | 7.30 |