Assay Detail
Binding
CHEMBL618130
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In vitro Binding affinity towards 5-hydroxytryptamine 3 receptor was determined
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Serotonin 3 (5-HT3) receptor (CHEMBL2094132) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Homo sapiens |
Publication
The 5-HT3 antagonist tropisetron (ICS 205-930) is a potent and selective alpha7 nicotinic receptor partial agonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 7.58 | 8.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL108799 | — | — | 1 | 8.96 |
| CHEMBL56564 | TROPISETRON | 3.0 | 1 | 8.28 |
| CHEMBL111583 | — | — | 1 | 8.14 |
| CHEMBL320963 | — | — | 1 | 8.00 |
| CHEMBL46 | ONDANSETRON | 4.0 | 1 | 7.92 |
| CHEMBL289469 | GRANISETRON | 4.0 | 1 | 7.62 |
| CHEMBL3 | NICOTINE | 4.0 | 1 | 4.15 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL108799 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL56564 | TROPISETRON | Ki | = | 5.3 | nM | 8.28 |
| CHEMBL111583 | — | Ki | = | 7.2 | nM | 8.14 |
| CHEMBL320963 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL46 | ONDANSETRON | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL289469 | GRANISETRON | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL3 | NICOTINE | Ki | = | 71000.0 | nM | 4.15 |