Assay Detail
Binding
CHEMBL618149
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity towards 5-hydroxytryptamine 3 receptor by displacement of [3H]2 in Neuroblastoma-Glioma NG-108-15 cells
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Thiazole as a carbonyl bioisostere. A novel class of highly potent and selective 5-HT3 receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 8.59 | 9.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL93919 | — | — | 1 | 9.38 |
| CHEMBL421747 | — | — | 1 | 9.00 |
| CHEMBL38465 | — | — | 1 | 8.74 |
| CHEMBL329179 | — | — | 1 | 8.71 |
| CHEMBL56564 | TROPISETRON | 3.0 | 1 | 8.57 |
| CHEMBL290938 | — | — | 1 | 7.92 |
| CHEMBL46 | ONDANSETRON | 4.0 | 1 | 7.79 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL93919 | — | Ki | = | 0.42 | nM | 9.38 |
| CHEMBL421747 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL38465 | — | Ki | = | 1.8 | nM | 8.74 |
| CHEMBL329179 | — | Ki | = | 1.94 | nM | 8.71 |
| CHEMBL56564 | TROPISETRON | Ki | = | 2.7 | nM | 8.57 |
| CHEMBL290938 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL46 | ONDANSETRON | Ki | = | 16.2 | nM | 7.79 |