Assay Detail
Binding
CHEMBL618152
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In vitro binding affinity for the 5-hydroxytryptamine 3 receptor was determined with NG-108-15 mouse neuroblastoma-glioma cells
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
An initial three-component pharmacophore for specific serotonin-3 receptor ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 8.50 | 9.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL18041 | ZACOPRIDE | 2.0 | 1 | 9.15 |
| CHEMBL56564 | TROPISETRON | 3.0 | 1 | 8.57 |
| CHEMBL40260 | — | — | 1 | 8.48 |
| CHEMBL46 | ONDANSETRON | 4.0 | 1 | 7.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL18041 | ZACOPRIDE | Ki | = | 0.7 | nM | 9.15 |
| CHEMBL56564 | TROPISETRON | Ki | = | 2.7 | nM | 8.57 |
| CHEMBL40260 | — | Ki | = | 3.3 | nM | 8.48 |
| CHEMBL46 | ONDANSETRON | Ki | = | 16.0 | nM | 7.80 |