Assay Detail
Binding
CHEMBL618163
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Binding affinity towards human recombinant 5-hydroxytryptamine 7 receptor was determined using [3H]5-CT as radioligand
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Optimization of the pharmacophore model for 5-HT7R antagonism. Design and synthesis of new naphtholactam and naphthosultam derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 7.74 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL69257 | — | — | 1 | 8.70 |
| CHEMBL428494 | — | — | 1 | 8.70 |
| CHEMBL12427 | — | — | 1 | 8.50 |
| CHEMBL273246 | — | — | 1 | 8.40 |
| CHEMBL13052 | — | — | 1 | 8.30 |
| CHEMBL12702 | — | — | 1 | 8.30 |
| CHEMBL268921 | — | — | 1 | 7.00 |
| CHEMBL273890 | — | — | 1 | 4.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL69257 | — | Ki | = | 1.995 | nM | 8.70 |
| CHEMBL428494 | — | Ki | = | 1.995 | nM | 8.70 |
| CHEMBL12427 | — | Ki | = | 3.162 | nM | 8.50 |
| CHEMBL273246 | — | Ki | = | 3.981 | nM | 8.40 |
| CHEMBL13052 | — | Ki | = | 5.012 | nM | 8.30 |
| CHEMBL12702 | — | Ki | = | 5.012 | nM | 8.30 |
| CHEMBL268921 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL273890 | — | Ki | = | 100000.0 | nM | 4.00 |