Assay Detail
Binding
CHEMBL618165
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Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand
40
Total Activities
40
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
2a-[4-(Tetrahydropyridoindol-2-yl)butyl]tetrahydrobenzindole derivatives: new selective antagonists of the 5-hydroxytryptamine7 receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 40 | 7.87 | 9.31 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL18840 | — | — | 1 | 9.31 |
| CHEMBL428494 | — | — | 1 | 8.73 |
| CHEMBL69257 | — | — | 1 | 8.67 |
| CHEMBL71847 | — | — | 1 | 8.63 |
| CHEMBL12427 | — | — | 1 | 8.48 |
| CHEMBL553794 | — | — | 1 | 8.45 |
| CHEMBL418888 | — | — | 1 | 8.45 |
| CHEMBL273246 | — | — | 1 | 8.42 |
| CHEMBL12846 | — | — | 1 | 8.40 |
| CHEMBL304731 | — | — | 1 | 8.32 |
| CHEMBL12702 | — | — | 1 | 8.29 |
| CHEMBL71383 | — | — | 1 | 8.24 |
| CHEMBL302766 | — | — | 1 | 8.22 |
| CHEMBL71225 | — | — | 1 | 8.19 |
| CHEMBL71959 | — | — | 1 | 8.15 |
| CHEMBL303166 | — | — | 1 | 8.10 |
| CHEMBL422587 | — | — | 1 | 8.09 |
| CHEMBL70889 | — | — | 1 | 8.06 |
| CHEMBL304167 | — | — | 1 | 7.98 |
| CHEMBL71057 | — | — | 1 | 7.91 |
| CHEMBL307101 | — | — | 1 | 7.91 |
| CHEMBL71224 | — | — | 1 | 7.77 |
| CHEMBL70869 | — | — | 1 | 7.76 |
| CHEMBL305526 | — | — | 1 | 7.72 |
| CHEMBL71170 | — | — | 1 | 7.72 |
| CHEMBL71390 | — | — | 1 | 7.69 |
| CHEMBL307352 | — | — | 1 | 7.66 |
| CHEMBL69040 | — | — | 1 | 7.62 |
| CHEMBL70819 | — | — | 1 | 7.60 |
| CHEMBL308461 | — | — | 1 | 7.53 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL18840 | — | Ki | = | 0.4898 | nM | 9.31 |
| CHEMBL428494 | — | Ki | = | 1.862 | nM | 8.73 |
| CHEMBL69257 | — | Ki | = | 2.138 | nM | 8.67 |
| CHEMBL71847 | — | Ki | = | 2.344 | nM | 8.63 |
| CHEMBL12427 | — | Ki | = | 3.311 | nM | 8.48 |
| CHEMBL553794 | — | Ki | = | 3.548 | nM | 8.45 |
| CHEMBL418888 | — | Ki | = | 3.548 | nM | 8.45 |
| CHEMBL273246 | — | Ki | = | 3.802 | nM | 8.42 |
| CHEMBL12846 | — | Ki | = | 3.981 | nM | 8.40 |
| CHEMBL304731 | — | Ki | = | 4.786 | nM | 8.32 |
| CHEMBL12702 | — | Ki | = | 5.129 | nM | 8.29 |
| CHEMBL71383 | — | Ki | = | 5.754 | nM | 8.24 |
| CHEMBL302766 | — | Ki | = | 6.026 | nM | 8.22 |
| CHEMBL71225 | — | Ki | = | 6.457 | nM | 8.19 |
| CHEMBL71959 | — | Ki | = | 7.079 | nM | 8.15 |
| CHEMBL303166 | — | Ki | = | 7.943 | nM | 8.10 |
| CHEMBL422587 | — | Ki | = | 8.128 | nM | 8.09 |
| CHEMBL70889 | — | Ki | = | 8.71 | nM | 8.06 |
| CHEMBL304167 | — | Ki | = | 10.47 | nM | 7.98 |
| CHEMBL307101 | — | Ki | = | 12.3 | nM | 7.91 |
| CHEMBL71057 | — | Ki | = | 12.3 | nM | 7.91 |
| CHEMBL71224 | — | Ki | = | 16.98 | nM | 7.77 |
| CHEMBL70869 | — | Ki | = | 17.38 | nM | 7.76 |
| CHEMBL305526 | — | Ki | = | 19.05 | nM | 7.72 |
| CHEMBL71170 | — | Ki | = | 19.05 | nM | 7.72 |
| CHEMBL71390 | — | Ki | = | 20.42 | nM | 7.69 |
| CHEMBL307352 | — | Ki | = | 21.88 | nM | 7.66 |
| CHEMBL69040 | — | Ki | = | 23.99 | nM | 7.62 |
| CHEMBL70819 | — | Ki | = | 25.12 | nM | 7.60 |
| CHEMBL308461 | — | Ki | = | 29.51 | nM | 7.53 |
| CHEMBL302093 | — | Ki | = | 43.65 | nM | 7.36 |
| CHEMBL72008 | — | Ki | = | 45.71 | nM | 7.34 |
| CHEMBL307686 | — | Ki | = | 72.44 | nM | 7.14 |
| CHEMBL69388 | — | Ki | = | 74.13 | nM | 7.13 |
| CHEMBL71165 | — | Ki | = | 97.72 | nM | 7.01 |
| CHEMBL70048 | — | Ki | = | 109.65 | nM | 6.96 |
| CHEMBL302723 | — | Ki | = | 147.91 | nM | 6.83 |
| CHEMBL68094 | — | Ki | = | 223.87 | nM | 6.65 |
| CHEMBL70764 | — | Ki | = | 416.87 | nM | 6.38 |
| CHEMBL273890 | — | Ki | < | 1000.0 | nM | - |