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Assay Detail

CHEMBL618216

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Compound was evaluated for inhibition constant, in liver microsomes from 3-methylcholanthrene-exposed rats
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Rattus norvegicus
Tissue Liver
Subcellular Microsome
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Effects of 1-arylpyrroles and naphthoflavones upon cytochrome P-450 dependent monooxygenase activities.
Viswanathan T, Alworth WL.
J Med Chem (1981) 24 : 822 -830
PubMed 7277387 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 6 6.63 7.77

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL283196 ALPHA-NAPHTHOFLAVONE 1 7.77
CHEMBL26260 BETA-NAPHTHOFLAVONE 1 7.58
CHEMBL275638 FLAVONE 2.0 1 7.48
CHEMBL166442 1 7.31
CHEMBL351713 1 4.96
CHEMBL14145 1 4.70

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL283196 ALPHA-NAPHTHOFLAVONE Ki = 17.0 nM 7.77
CHEMBL26260 BETA-NAPHTHOFLAVONE Ki = 26.0 nM 7.58
CHEMBL275638 FLAVONE Ki = 33.0 nM 7.48
CHEMBL166442 Ki = 49.0 nM 7.31
CHEMBL351713 Ki = 11000.0 nM 4.96
CHEMBL14145 Ki = 20000.0 nM 4.70