Assay Detail
Binding
CHEMBL618403
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Inhibitory activity against 5-lipoxygenase.
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Polyunsaturated fatty acid 5-lipoxygenase (CHEMBL215) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Structure-activity relationships of the pyridazinone series of 5-lipoxygenase inhibitors
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 32 | 5.08 | 6.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL30244 | — | — | 1 | 6.14 |
| CHEMBL29605 | — | — | 1 | 5.96 |
| CHEMBL26084 | — | — | 1 | 5.89 |
| CHEMBL29413 | — | — | 1 | 5.75 |
| CHEMBL7660 | PHENIDONE | — | 1 | 5.72 |
| CHEMBL26083 | — | — | 1 | 5.60 |
| CHEMBL27409 | — | — | 1 | 5.52 |
| CHEMBL30151 | — | — | 1 | 5.47 |
| CHEMBL29508 | — | — | 1 | 5.46 |
| CHEMBL285098 | — | — | 1 | 5.43 |
| CHEMBL30110 | — | — | 1 | 5.42 |
| CHEMBL282558 | — | — | 1 | 5.28 |
| CHEMBL26204 | — | — | 1 | 5.26 |
| CHEMBL287426 | — | — | 1 | 5.25 |
| CHEMBL25790 | — | — | 1 | 5.22 |
| CHEMBL29544 | — | — | 1 | 5.17 |
| CHEMBL26143 | — | — | 1 | 5.09 |
| CHEMBL30067 | — | — | 1 | 5.03 |
| CHEMBL177584 | — | — | 1 | 4.82 |
| CHEMBL27411 | — | — | 1 | 4.72 |
| CHEMBL30202 | — | — | 1 | 4.64 |
| CHEMBL29874 | — | — | 1 | 4.41 |
| CHEMBL281981 | — | — | 1 | 4.28 |
| CHEMBL26851 | — | — | 1 | 4.28 |
| CHEMBL281259 | — | — | 1 | 4.24 |
| CHEMBL30131 | — | — | 1 | 4.19 |
| CHEMBL283419 | — | — | 1 | 4.10 |
| CHEMBL27410 | — | — | 1 | 4.00 |
| CHEMBL432466 | — | — | 1 | - |
| CHEMBL29414 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL30244 | — | IC50 | = | 730.0 | nM | 6.14 |
| CHEMBL29605 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL26084 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL29413 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL7660 | PHENIDONE | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL26083 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL27409 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL30151 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL29508 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL285098 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL30110 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL282558 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL26204 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL287426 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL25790 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL29544 | — | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL26143 | — | IC50 | = | 8200.0 | nM | 5.09 |
| CHEMBL30067 | — | IC50 | = | 9300.0 | nM | 5.03 |
| CHEMBL177584 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL27411 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL30202 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL29874 | — | IC50 | = | 39000.0 | nM | 4.41 |
| CHEMBL281981 | — | IC50 | = | 53000.0 | nM | 4.28 |
| CHEMBL26851 | — | IC50 | = | 52000.0 | nM | 4.28 |
| CHEMBL281259 | — | IC50 | = | 57000.0 | nM | 4.24 |
| CHEMBL30131 | — | IC50 | = | 65000.0 | nM | 4.19 |
| CHEMBL283419 | — | IC50 | = | 79000.0 | nM | 4.10 |
| CHEMBL27410 | — | IC50 | = | 99000.0 | nM | 4.00 |
| CHEMBL432466 | — | IC50 | = | 277000.0 | nM | - |
| CHEMBL29414 | — | IC50 | = | 156000.0 | nM | - |
| CHEMBL28579 | — | IC50 | = | 204000.0 | nM | - |
| CHEMBL29939 | — | IC50 | = | 125000.0 | nM | - |