Assay Detail
Functional
CHEMBL618432
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Antitumor activity against human bladder carcinoma 5637 cells
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | 5637 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Antitumor agents. 1. Synthesis, biological evaluation, and molecular modeling of 5H-pyrido[3,2-a]phenoxazin-5-one, a compound with potent antiproliferative activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.78 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1554 | DACTINOMYCIN | 4.0 | 1 | 8.52 |
| CHEMBL151423 | — | — | 1 | 8.00 |
| CHEMBL348434 | — | — | 1 | 6.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1554 | DACTINOMYCIN | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL151423 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL348434 | — | IC50 | = | 150.0 | nM | 6.82 |