Assay Detail
Functional
CHEMBL618448
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Concentration of the drug to inhibit chinese hamster ovary derived cell (AA8) growth in culture
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cricetulus griseus |
| Cell Type | CHO-AA8 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
DNA-directed alkylating agents. 6. Synthesis and antitumor activity of DNA minor groove-targeted aniline mustard analogues of pibenzimol (Hoechst 33258)
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.80 | 6.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL138738 | — | — | 1 | 6.48 |
| CHEMBL136144 | — | — | 1 | 6.40 |
| CHEMBL335278 | — | — | 1 | 5.88 |
| CHEMBL137445 | — | — | 1 | 5.82 |
| CHEMBL138595 | — | — | 1 | 5.78 |
| CHEMBL134422 | — | — | 1 | 5.24 |
| CHEMBL137443 | — | — | 1 | 5.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL138738 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL136144 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL335278 | — | IC50 | = | 1320.0 | nM | 5.88 |
| CHEMBL137445 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL138595 | — | IC50 | = | 1680.0 | nM | 5.78 |
| CHEMBL134422 | — | IC50 | = | 5750.0 | nM | 5.24 |
| CHEMBL137443 | — | IC50 | = | 10000.0 | nM | 5.00 |