Assay Detail
Functional
CHEMBL618641
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In vitro cellular toxicity against chinese hamster AA8 cell line after 4 hr of compound exposure
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cricetulus griseus |
| Cell Type | CHO-AA8 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Unsymmetrical DNA cross-linking agents: combination of the CBI and PBD pharmacophores.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 7.39 | 10.27 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL302536 | — | — | 1 | 10.27 |
| CHEMBL302363 | — | — | 1 | 9.89 |
| CHEMBL66051 | — | — | 1 | 9.68 |
| CHEMBL432909 | — | — | 1 | 8.40 |
| CHEMBL307572 | — | — | 1 | 8.38 |
| CHEMBL70011 | — | — | 1 | 7.96 |
| CHEMBL307801 | — | — | 1 | 7.54 |
| CHEMBL69443 | — | — | 1 | 7.40 |
| CHEMBL69680 | — | — | 1 | 7.32 |
| CHEMBL305208 | — | — | 1 | 6.68 |
| CHEMBL307542 | — | — | 1 | 6.62 |
| CHEMBL279754 | DSB-120 | — | 1 | 6.47 |
| CHEMBL70019 | — | — | 1 | 5.80 |
| CHEMBL293096 | — | — | 1 | 5.70 |
| CHEMBL302819 | — | — | 1 | 5.35 |
| CHEMBL66736 | — | — | 1 | 4.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL302536 | — | IC50 | = | 0.054 | nM | 10.27 |
| CHEMBL302363 | — | IC50 | = | 0.13 | nM | 9.89 |
| CHEMBL66051 | — | IC50 | = | 0.21 | nM | 9.68 |
| CHEMBL432909 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL307572 | — | IC50 | = | 4.2 | nM | 8.38 |
| CHEMBL70011 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL307801 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL69443 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL69680 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL305208 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL307542 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL279754 | DSB-120 | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL70019 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL293096 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL302819 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL66736 | — | IC50 | = | 14000.0 | nM | 4.85 |