Assay Detail
Binding
CHEMBL618765
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of 5-Lipoxygenase (5-LOX)
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Polyunsaturated fatty acid 5-lipoxygenase (CHEMBL215) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
New cyclooxygenase-2/5-lipoxygenase inhibitors. 3. 7-tert-butyl-2, 3-dihydro-3,3-dimethylbenzofuran derivatives as gastrointestinal safe antiinflammatory and analgesic agents: variations at the 5 position.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 4.97 | 5.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL13878 | TEBUFELONE | 2.0 | 1 | 5.52 |
| CHEMBL2112567 | — | — | 1 | 5.40 |
| CHEMBL117911 | — | — | 1 | 5.22 |
| CHEMBL326295 | — | — | 1 | 5.12 |
| CHEMBL118839 | — | — | 1 | 5.05 |
| CHEMBL332028 | — | — | 1 | 5.00 |
| CHEMBL332937 | — | — | 1 | 5.00 |
| CHEMBL119433 | — | — | 1 | 4.92 |
| CHEMBL117615 | — | — | 1 | 4.66 |
| CHEMBL422075 | — | — | 1 | 4.52 |
| CHEMBL419947 | — | — | 1 | 4.30 |
| CHEMBL119170 | — | — | 1 | - |
| CHEMBL122065 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL13878 | TEBUFELONE | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL2112567 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL117911 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL326295 | — | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL118839 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL332028 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL332937 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL119433 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL117615 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL422075 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL419947 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL119170 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL122065 | — | IC50 | > | 50000.0 | nM | - |