Assay Detail
Binding
CHEMBL618891
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Binding affinity for 5-hydroxytryptamine 3 receptor by displacement of [3H](R)-zacopride from ondansetron-treated NG-108-15 cell membranes
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
(R)-3-(6-chloro-1-isopropylbenzimidazole-4-carboxamido)quinuclidine: A high affinity ligand for the (R)-zacopride binding site
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 7.47 | 9.84 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL145725 | — | — | 1 | 9.84 |
| CHEMBL27846 | (R)ZACOPRIDE | — | 1 | 8.30 |
| CHEMBL142852 | — | — | 1 | 7.70 |
| CHEMBL145033 | — | — | 1 | 6.22 |
| CHEMBL28992 | — | — | 1 | 5.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL145725 | — | Ki | = | 0.1445 | nM | 9.84 |
| CHEMBL27846 | (R)ZACOPRIDE | Ki | = | 5.012 | nM | 8.30 |
| CHEMBL142852 | — | Ki | = | 19.95 | nM | 7.70 |
| CHEMBL145033 | — | Ki | = | 602.56 | nM | 6.22 |
| CHEMBL28992 | — | Ki | = | 5011.87 | nM | 5.30 |